Headache Medicine with Nighttime Sleep Aid Excedrin PM Headache Relief with Sleep Aid Caplets end nighttime headaches fast to help you fall asleep. With a caffeine-free triple action formula that combines two effective pain relievers with a non habit forming sleep aid this headache medicine contains aspirin acetaminophen and diphenhydramine citrate. These active ingredients work together to provide temporary nighttime pain relief of occasional headaches and minor aches and pains accompanied by sleeplessness. Get fast relief from your headache with this pain reliever for headaches and nighttime sleep aid.