SAMe (S-adenosylmethionine) a compound native to the body is a critical component of many biochemical reactions including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition because SAMe is also necessary for the synthesis of neurotransmitters it plays an important role in mood support. NOW? SAMe is enteric-coated which makes it very well tolerated and protects it from degradation.*Not manufactured with wheat gluten soy milk egg fish shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Do Not Eat Freshness Packet. Keep in Bottle. Caution: For adults only. IndividU?als with bipolar (manic) depression and those with anxiety disorders should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing taking medication or have a medical cond